Glutamate toxicity and meningitis

23 July 2013 at 09:00:00 by sarissa2

Sarissa's glutamate biosensors used to measure glutamate release in brain in a model of meningitis. The authors show that pneumolysin causes glutamate release from astrocytes and induce excytotoxic damage. See the paper:

Wippel C, Maurer J, Fortsch C, Hupp S, Bohl A, Ma J, Mitchell TJ, Bunkowski S, Bruck W, Nau R, Iliev AI (2013) Bacterial Cytolysin during Meningitis Disrupts the Regulation of Glutamate in the Brain, Leading to Synaptic Damage. PLoS pathogens 9:e1003380.

Back to listing
bit10 logo