Recent Publications

General Reviews

• Dale, N., Hatz, S., Tian, F., and Llaudet, E., (2005) Listening to the brain: microelectrode biosensors for neurochemicals. Trends Biotechnol 23:420-428.
• Dale N., Llaudet, E. and Hatz, S. (2006) Microelectrode biosensors for analysis of biological signaling. Encyclopedia of Sensors 6:139-152.

ATP Sensor Papers

• Schock SC, Munyao N, Yakubchyk Y, Sabourin LA, Hakim AM, Ventureyra ECG, Thompson CS (2007) Cortical spreading depression releases ATP into the extracellular space and purinergic receptor activation contributes to the induction of ischemic tolerance. Brain Res 1168:129-138.
• Gourine, A.V., Dale, N., Llaudet, E., Poputnikov, D., Spyer, K.M., Gourine, V.N. ( 2007) Release of ATP in the central nervous system during systemic inflammation: Real-time measurement in the hypothalamus of conscious rabbits. J Physiol 585:305-326
• Massé, K., Bhamra, S., Eason, R., Dale, N. and Jones, E. (2007) Purine-mediated signalling triggers eye development. Nature 449:1058-1062.
• Frenguelli, B.G., Wigmore, G., Llaudet, E., and Dale, N. (2007). Temporal and mechanistic dissociation of ATP and adenosine release during ischemia in the mammalian hippocampus. J Neurochem 101:1400-1413.
• Gourine, A.V., Llaudet, E., Dale, N., and Spyer, K.M. (2005) ATP is mediator of chemosensory transduction in the central nervous system. Nature 436:108-111.
• Pearson, R.A., Dale, N., Llaudet, E. & Mobbs, P. (2005) ATP released via gap junction hemichannels from the pigment epithelium regulates neural retina progenitor proliferation. Neuron 46:731-744.
• Llaudet, E., Hatz, S., Droniou, M. & Dale, N. (2005) Microelectrode biosensor for real-time measurement of ATP in biological tissue. Anal Chem 77:3267-3273.
• Gourine, A.V., Llaudet, E., Dale, N., and Spyer, K.M. (2005). Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response. J Neurosci 25:1211-1218.

ADO Sensor Papers

• Bekar, L., Libionka. W., Tian, G.F., Xu, Q., Torres, A., Wang, X., Lovatt, D., Williams, E., Takano, T., Schnermann, J., Bakos. R. and Nedergaard, M. (2008) Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor. Nature Medicine 14:75-80.
• Lin, J.H., Lou, N., Kang, N., Takano, T., Hu, F., Han, X., Xu, Q., Lovatt, D., Torres, A., Willecke, K., Yang, J., Kang, J. and Nedergaard, M. (2008) A central role of connexin 43 in hypoxic preconditioning. J Neurosci 28:681-695.
• Wall, M., Atterbury, A. and Dale, N. (2007) Control of basal extracellular adenosine concentration in rat cerebellum. J Physiol 582:137-151.
• Wall, M. and Dale, N. (2007) Auto-inhibition of parallel fibre-Purkinje cell synapses by activity dependent adenosine release. J Physiol 581:553-565.
• Llaudet, E., Botting, N.P., Crayston, J.A., and Dale, N. (2003). A three-enzyme microelectrode sensor for detecting purine release from central nervous system. Biosens Bioelectron 18:43-52.
• Frenguelli, B.G., Llaudet, E., and Dale, N. (2003). High-resolution real-time recording with microelectrode biosensors reveals novel aspects of adenosine release during hypoxia in rat hippocampal slices. J Neurochem 86:1506-1515.
• Gourine, A.V., Llaudet, E., Thomas, T., Dale, N., and Spyer, K.M. (2002). Adenosine release in nucleus tractus solitarii does not appear to mediate hypoxia-induced respiratory depression in rats. J Physiol 544:161-170.
• Dale, N., Gourine, A.V., Llaudet, E., Bulmer, D., Thomas, T., and Spyer, K.M. (2002). Rapid adenosine release in the nucleus tractus solitarii during defence response in rats: real-time measurement in vivo . J Physiol 544:149-160.
• Begg, M., Dale, N., Llaudet, E., Molleman, A., and Parsons, M.E. (2002). Modulation of the release of endogenous adenosine by cannabinoids in the myenteric plexus-longitudinal muscle preparation of the guinea-pig ileum. Br J Pharmacol 137:1298-1304.

Adenosine Sensor Papers

• Pearson T, Damian K, Lynas RE, Frenguelli BG (2006) Sustained elevation of extracellular adenosine and activation of A1 receptors underlie post-ischaemic inhibition of neuronal function in rat hippocampus in vitro. J Neurochem 97:1357:1368.
• Dulla CG, Dobelis P, Pearson T, Frenguelli BG, Staley KJ, Masino SA (2005) Adenosine and ATP link PCO2 to cortical excitability via pH. Neuron 48:1011-1023.
• Pearson T, Frenguelli BG (2004) Adrenoceptor subtype-specific acceleration of the hypoxic depression of excitatory synaptic transmission in area CA1 of the rat hippocampus. Eur J Neurosci 20:1555-1565.
• Pearson, T., Nuritova, F., Caldwell, D., Dale, N., and Frenguelli, B.G. (2001). A depletable pool of adenosine in area CA1 of the rat hippocampus. J Neurosci 21:2298-2307.
• Dale, N., Pearson, T., and Frenguelli, B.G. (2000). Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice. J Physiol 526:143-155.
• Dale, N. (1998). Delayed production of adenosine underlies temporal modulation of swimming in frog embryo. J Physiol 511:265-272.