Sarissa Biomedical: e-newsletter # 3

WELCOME
NEWS:
e-commerce site / new order codes / dollar pricelist
FEATURED PAPERS
ABOUT US

Dear Reader,

Welcome to our third newsletter. Again, there have been changes at Sarissa Biomedical since we were last in touch. We've strengthened the team with our new accountant, Mr. David Paxton. David has been working for us part-time over the last couple of months and been a fantastic addition to the company. Welcome aboard, David.

Ssales of our new 25µm: sensors sensors - first mentioned in our last newsletter - have been very positive. Having spoken to some of our customers, we're very happy to report that they have been very well received. The extra price over the 50µm sensors is recognised to be good value for the increased flexibility in usage and performance.

You may remember our collaborative agreement with Pinnacle Technology Inc. in the US. Well we are happy to announce that we are looking to ship our first batch of Pinnacle sensors. We understand that we have a impressive number of new customers as a result of our new agreement with Pinnacle. If you are one of these excited new customers, bear with us both. We're nearly there!

As ever, we would appreciate your feedback. As a small business, we're particularly appreciative of our customer's positive feedback when we recieve it, and try and do our best to react as quickly as possible to improvements to our products and services. As ever, we really would appreciate your feedback on anything relating to our business - however small.

kind regards,

Chris Buck
Sales & Marketing Manager

NEWS

E-commerce site goes live

It's been a while coming but we have just launched our new e-commerce site. Customers can now order online which will streamline your ordering process and our fullfilment process. As a small business, we're expecting it to make quite a difference to our efficiency.

Customers will be able to pay using a credit card or debit card using PayPal as the payment provider. Happy shopping at www.sarissa-biomedical.com!

New Product Codes

Whilst improving our website, we thought we'd also make our product codes more intelligible. To begin with we have broken our current product range down into 3 distinct groups: sensors, kits, and factored products. Each of these are represented using the following prefixes:

Sensors = SBS
Kits = SBK
Factored products = SBF

Thereafter, our sensors are described as follows:

Adenosine triphosphate = ATP
Adenosine = ADO
Inosine = INO
Acetylcholine = ACH
Choline = CHO
Glutamate = GLU
Hypoxanthine = HYP

Penultimately, the length of the sensor is given:

0.5 = 0.5mm
2.0 = 2.0mm

Finally, the diameter of the sensor is given in µm:

50 = 50 µm
25 = 25 µm

When combined together, a typical order code will look something like this:

SBS-ATP-05-25

which represents a pack of adenosine triphosphate sesnsors, each of which is 0.5mm long and 25 µm in diameter. We recommend that you take this opportunity to glance through our new pricelists for a clearer understanding, more of which, below.....

US Dollar pricelist

In response to our customers' requests, we now have a specific US Dollar pricelist. This can be found here:

$USD

FEATURED PAPERS

	Gourine AV, Dale N, Korsak A, Llaudet E, Tian F, Huckstepp R, Spyer KM. Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway J Physiol. 2008 Aug 15;586(16):3963-78. Epub 2008 Jul 10. Breuer-Hering inflation reflex is initiated by activation of the slowly adapting pulmonary stretch receptor afferents (SARs), which monosynaptically activate second-order relay neurones in the dorsal medullary nucleus of the solitary tract (NTS). Here we demonstrate that during lung inflation SARs release both ATP and glutamate from their central terminals to activate these NTS neurones. MORE...

	Dale N. Dynamic ATP Signalling and Neural Development. J Physiol. 2008 May 15;586(10):2429-36. Epub 2008 Mar 20. Purinergic signalling plays a major role in the function of every organ including the brain. A growing body of evidence also suggests that purinergic signalling is important in the development of the retina, cochlea and neocortex. In these three contexts release of ATP through the spontaneous gating of connexin hemichannels in cells, respectively, of the retinal pigment epithelium, Köllicker's organ, and the radial glia triggers waves of intracellular Ca2+ release. MORE...

N.B. For a regularly updated list of recent publictions featuring Sarissaprobes© please keep an eye on our website, here: www.sarissa-biomedical.com/recent-publications.php

About Sarissa Biomedical Ltd
The sarissaprobe™ range remains focused on producing tools for investigating purinergic signaling. We offer biosensors for a range of purines: ATP, adenosine, inosine, hypoxanthine. However we have expanded our range to cover other transmitters. We currently sell acetylcholine biosensors and, given suitable demand, we can supply biosensors for glutamate and lactate. All our sensors are available in 0.5 and 2mm lengths. The shorter sensors are very suitable for use with brain slices, while the longer lengths of sensor can be better for in vivo recordings. Custom sensor sizes or shapes are possible. Future developments in the pipeline at Sarissa include production of a range of biosensors aimed at real-time measurement of gliotransmitter release.
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