Sarissa Biomedical: e-newsletter # 2

Dear Reader,

Welcome to our second newsletter. We've had lots going on behind the scenes since we were last in touch. First to mind, is our new 25µm sensors which have very recently gone on sale. Exceptional quality sensors - now exceptionally thin! Watch our product pages on our website for pricing and purchasing information.

Talking of our website, you may well notice that we've given it a considerable revamp over the last few weeks. We would appreciate your feedback and any further suggestions for content.

We are also very pleased to announce a collaborative agreement with Pinnacle Technology Inc. in the US. In essence it is an agreement which enables us access to new market territories whilst also adding value to Pinnacle's existing product line using our patented coating process.

Last but not least we welcome our new Research and Development Technician, Wenjue Wu. She will be replacing Mr. Jan Lopotar, who left to pursue a PhD. We wish Jan all the very best with his research and thank him for all of his hard work over the last 18 months. Similaraly, we welcome Wenjue into the fold and thank her for her contribution thus far.

kind regards,

Chris Buck
Sales & Marketing Manager

News

New Collaborative Partnership with Pinnacle Technology Inc.

Sarissa Biomedical is very pleased to have signed a new collaborative working agreement with Pinnacle Technology Inc. which will see the very best of the two companies's skill sets in force. Pinnacle is a significant manufacturer and re-reseller of biosensors around the globe, and a maker of instrumentation for behavioural recordings from freely moving rodents. The company is pleased to able to acccess Sarissa's patented coating technology. Sarissa Biomedical's founder, Prof. Nick Dale commented:

"With our coating expertise, we're very confident we can add value to Pinnacle Techology's biosensor portfolio. In return, we will gain much wider access to new markets in which we can showcase our own biosensor products... I've known Donna [Johnson] - the President of Pinnacle Technology - for a while now, and although the agreement took a while to formulate, we both think it was worth the wait. We are both very excited about the future for both our respective businesses."

Prof. Nick Dale, Founder, Sarissa Biomedical Ltd

"Pinnacle is excited to be working with Sarissa. We have developed turnkey wireless data acquisition systems for our sensors. By adding Sarissa's coating technology to our sensor blanks, we will be able to provide our customers with a variety of new sensors that are fully compatible with our hardware. This is a clear win for Sarissa, Pinnacle, and most importantly, for our customers."

Donna Johnson, President, Pinnacle Technology Inc.

New 25µm sensors

Recently we have added a third product offering to our impressive range of sensors - the addition of a 25 µm diameter sensor which is now available throughout our whole range including Acetylcholine, Adenosine, Adenosine Triphosphate, Inosine, Choline, Glutamate, and Hypoxanthine.

25 micron sensors

The new 25µm Ų sensor from Sarissa Biomedical Ltd

Over the coming weeks we'll be updating you with specifications of our range of sensors including specifications, order codes, and prices.

needle shaped electrode (Pt/Ir wire)
sensor length 0.5mm x 25µm Ų
response time: 10-90% rise time ≤ 10 sec
LOD: 200nM
linear range: 0.5 µM to 50 µM
shelf-life (dry): ≥ 6 months @ 4° C
shelf-life (wet): ≤ 5 days
calibration: single point
re-use: subject to calibration
applications: in vitro, in vivo
tissues: brain; blood vessels; gut; retina

New Website

new improved (and improving!) www.sarissa-biomedical.com

Over the last couple of months we've been working hard to transform our website into a useful repository for our customers. Apart from becoming a direct sales channel for our growing family of exceptional sensors and related technology, we hope it will provide some of the most relevant publications for our customers' work with bio-sensors. We will also be publishing more training materials, and important research-related updates.

From the feedback we've had so far, people are suitably impressed. Coming very soon is the e-commerce functionality. We've responded to customer requests for online ordering and elected to use Paypal as our payment provider. This will enable purchases using Visa, Mastercard and American Express.

We would welcome your input into further developments of the site. If you have an opinion, then please do let us know.

Featured Papers

	Bekar, L., Libionka. W., Tian, G.F., Xu, Q., Torres, A., Wang, X., Lovatt, D., Williams, E., Takano, T., Schnermann, J., Bakos. R. and Nedergaard, M. Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor. Nature Medicine 14:75-80, 2008

	Gourine, A.V., Dale, N., Llaudet, E., Poputnikov, D., Spyer, K.M., Gourine, V.N. Release of ATP in the central nervous system during systemic inflammation: Real-time measurement in the hypothalamus of conscious rabbits. J Physiol Volume 585, Number 1, 305-316, DOI: 10.1113/jphysiol.2007.143933, November 15, 2007

	Massé, K., Bhamra, S., Eason, R., Dale, N. and Jones, E. Purine-mediated signalling triggers eye development. Nature 449:1058-1062. (2007)

	Wall, M., Atterbury, A. and Dale, N. Auto-inhibition of parallel fibre-Purkinje cell synapses by activity dependent adenosine releasetext J Physiol 581:553-565. (2007)

N.B. For a regularly updated list of recent publictions featuring Sarissaprobes© please keep an eye on our website, here: www.sarissa-biomedical.com/recent-publications.htm

About Sarissa Biomedical Ltd
The sarissaprobe™ range remains focused on producing tools for investigating purinergic signaling. We offer biosensors for a range of purines: ATP, adenosine, inosine, hypoxanthine. However we have expanded our range to cover other transmitters. We currently sell acetylcholine biosensors and, given suitable demand, we can supply biosensors for glutamate and lactate. All our sensors are available in 0.5 and 2mm lengths. The shorter sensors are very suitable for use with brain slices, while the longer lengths of sensor can be better for in vivo recordings. Custom sensor sizes or shapes are possible. Future developments in the pipeline at Sarissa include production of a range of biosensors aimed at real-time measurement of gliotransmitter release.
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